Top 10 Endpoint Security Vendors for CMMC Compliance in 2026

Organizations face increasing challenges in meeting the Cybersecurity Maturity Model Certification (CMMC) compliance requirements. These challenges are intentional; non-compliance can jeopardize the security and authenticity of CUI and FCI, potentially putting national security at risk.

In this post, we’ll highlight ten leading vendors that provide comprehensive solutions to help streamline CMMC compliance efforts.

Executive Summary

Main idea: This post highlights 10 leading endpoint security vendors that help organizations achieve CMMC compliance and protect Controlled Unclassified Information (CUI), with guidance on why endpoint security is central to measurable, auditable compliance.

Why you should care: DoD contracts increasingly require CMMC. Effective endpoint security reduces breach risk, safeguards CUI, accelerates audits, and helps avoid lost revenue, penalties, and reputational damage.

Key Takeaways

1. Endpoint security is foundational to CMMC. Robust prevention, detection, and response on endpoints provide the continuous monitoring and evidence that audits demand.
2. Protecting CUI is the real objective. Beyond passing audits, organizations must prevent theft, tampering, and unauthorized sharing of CUI across devices and collaboration channels.
3. Consolidation and visibility simplify compliance. Unified telemetry, policies, and reporting reduce complexity, streamline evidence collection, and speed investigations.
4. Match vendor strengths to your environment and controls. Choose capabilities that align with NIST SP 800-171 requirements, deployment needs, and your team’s operational model.
5. Kiteworks unifies secure data exchange with governance. Its Private Data Network centralizes secure file sharing, MFT, and email with zero-trust controls and comprehensive auditing for CMMC.

Why Securing Endpoints Matters for CMMC and CUI

Endpoints are where data is created, accessed, and frequently exfiltrated. CMMC centers on verifiable control of systems processing Federal Contract Information (FCI) and CUI—making endpoint hardening, monitoring, and response critical to both compliance and real risk reduction.

Key risks of insufficient endpoint security:

• CUI exfiltration via malware, phishing, or unauthorized apps
• Ransomware disruptions, data tampering, and costly incident response
• Lateral movement that compromises broader networks and suppliers
• Audit findings from missing logs, weak access controls, or inconsistent policies
• Loss of DoD opportunities and reputational damage

Benefits of strong endpoint security:

• Measurable reduction in attack surface and dwell time
• Continuous telemetry, alerting, and automated response to contain threats
• Clear, tamper-evident logging for investigations and audits
• Consistent policy enforcement across devices, users, and locations
• Protected collaboration workflows that keep FCI/CUI within governance boundaries

Vendor-by-capability matrix

Legend: Yes = native capability; Partial = available with limitations; Via integration = supported through platform/ecosystem integration; — = not primary capability.

Risk-to-control mapping

1. Kiteworks

Kiteworks equips enterprises and regulated organizations with a unified Private Data Network, ensuring secure file sharing, email, and managed transfers that protect sensitive information. With support for CMMC compliance, Kiteworks stands out through its end-to-end encryption and zero-trust access controls, offering detailed audit trails and chain-of-custody visibility for complete oversight.

Kiteworks’ Private Data Network unifies secure file sharing, managed file transfer (MFT), secure email, SFTP, and APIs under one governance umbrella. Granular, least-privilege access, MFA/SSO, policy-based controls, malware scanning, and DLP integrations safeguard FCI/CUI. Centralized, tamper-evident audit logging and chain-of-custody evidence support assessments and investigations. Deploy on-premises or single-tenant private cloud.

2. CrowdStrike

CrowdStrike is known for its Falcon platform, which provides endpoint protection through advanced threat intelligence and analytics. Its ability to detect and respond to threats in real time makes it a trusted choice for many organizations striving for compliance.

Falcon combines NGAV, EDR/XDR, identity protection, and managed threat hunting (OverWatch) with rich threat intelligence. Continuous telemetry and behavioral analytics detect ransomware, fileless attacks, and lateral movement. Device control, vulnerability insights, and real-time response accelerate containment and remediation. Robust APIs and dashboards help evidence monitoring, incident handling, and endpoint posture for audits.

3. Microsoft

Microsoft offers robust endpoint security features integrated within its Microsoft 365 suite. The combination of tools such as Microsoft Defender for Endpoint allows organizations to secure their devices and data while ensuring compliance with various regulations.

Defender for Endpoint integrates with Intune, Entra ID (MFA/Conditional Access), and Microsoft Purview for DLP and Information Protection. Attack surface reduction, endpoint baselines, vulnerability management, and automated investigation/remediation strengthen device hygiene. Unified telemetry across M365 services streamlines detection, response, and reporting. Built-in audit logs and compliance reports help map to NIST SP 800-171 practices relevant to CMMC.

4. PreVeil

PreVeil delivers end-to-end encrypted email and file collaboration tailored for regulated industries, including organizations pursuing CMMC. It focuses on protecting CUI by securing communications and documents with strong encryption and granular access controls while preserving usability for end users and administrators.

PreVeil Mail and Drive provide zero-trust sharing with least-privilege access, MFA/SSO options, and tamper-evident logging. Native Outlook and mobile integrations promote adoption without sacrificing encryption. Administrative controls, approval workflows, and retention help govern CUI. APIs and partner integrations complement EDR, DLP, and SIEM to centralize evidence for audits and maintain chain-of-custody visibility.

5. Drata

Drata is a continuous compliance automation platform that helps organizations operationalize frameworks such as NIST SP 800-171 and CMMC. While not an endpoint security tool, Drata centralizes evidence collection and control monitoring across your endpoint, identity, and cloud stack to sustain compliance readiness.

Pre-built integrations with EDR, MDM, identity, ticketing, and vulnerability tools synchronize asset posture, access reviews, and remediation workflows. Automated evidence collection, custom controls, and auditor workspaces streamline assessments. Real-time dashboards, alerts, and detailed audit logs reduce manual effort, expose gaps tied to endpoints, and document conformance for measurable, auditable compliance.

6. Cybereason

Cybereason focuses on a behavioral-based approach, enhancing its endpoint detection and response solutions. This method helps organizations identify and mitigate compliance risks associated with various cyber threats.

Cybereason’s MalOp engine correlates activity across devices to visualize attack progressions. Its EDR/NGAV stack blocks ransomware, fileless attacks, and lateral movement, with rapid isolation and guided remediation. MDR services augment internal teams. Detailed endpoint telemetry and retention bolster auditability, while role-based access and policy controls help enforce least privilege and safeguard CUI on dispersed endpoints.

7. Vanta

Vanta provides security and compliance automation that accelerates readiness for frameworks including NIST SP 800-171/CMMC. It complements endpoint platforms by continuously assessing controls, collecting artifacts, and surfacing risks that affect protection of CUI.

Extensive integrations connect to EDR/XDR, MDM, cloud, and identity systems to verify configurations, patch levels, and access policies. Policy templates, automated tests, and evidence repositories simplify audit preparation. Role-based access, change histories, and reporting create a defensible trail while aligning teams on remediation linked to endpoint security outcomes.

8. Bitdefender

With its advanced endpoint protection solutions, Bitdefender offers features including anti-malware, data protection, and threat detection. This ensures that organizations remain compliant while securing sensitive information.

Bitdefender GravityZone unifies NGAV, EDR/XDR, risk analytics, and ransomware mitigation with network attack defense and sandboxing. Integrated patch management, full-disk encryption options, and device/application control help harden endpoints. Lightweight agents minimize performance impact. Centralized reporting and role-based access aid separation of duties, evidence collection, and continuous monitoring aligned to CMMC expectations.

9. Carbon Black (VMware)

Carbon Black, a VMware product, uses cloud-native endpoint detection and response capabilities. This allows organizations to maintain compliance by effectively managing and protecting endpoints from evolving threats.

VMware Carbon Black’s cloud-native EDR provides continuous recording, behavioral analytics, and rapid live response for remote remediation. Application control and device control reduce unauthorized execution and data exfiltration risks. Flexible policies, threat hunting, and detailed audit trails help demonstrate monitoring and incident handling. Integrations across VMware ecosystems improve visibility and help standardize controls in virtualized environments.

10. Sophos

Sophos provides endpoint security solutions that unify threat detection and response. Its advanced tools help organizations streamline compliance with regulatory requirements while safeguarding sensitive data.

Sophos Intercept X combines deep learning anti-malware, exploit prevention, and CryptoGuard ransomware rollback with EDR/XDR visibility. Synchronized Security shares telemetry with Sophos Firewall for coordinated response. Optional Managed Threat Response (MTR) provides 24/7 monitoring. Device encryption, web and application control, and policy-based isolation strengthen protection and yield evidence for audits and continuous improvement.

Kiteworks Accelerates CMMC Compliance and CUI Protection

When choosing an endpoint security vendor, organizations must consider the specific compliance requirements they are facing, including CMMC. Kiteworks offers a comprehensive solution tailored to meet those needs with its Private Data Network. By prioritizing rigorous security and compliance, organizations can protect their sensitive information while maintaining productivity.

Kiteworks’ Private Data Network centralizes governance for secure file sharing, managed file transfer, and secure email with end-to-end encryption, zero-trust access controls, and granular policies that protect FCI and CUI wherever they travel. It helps align with NIST SP 800-171 practices foundational to CMMC by enforcing least privilege, MFA/SSO, data classification/DLP integrations, and content-based restrictions.

Tamper-evident audit logs, chain-of-custody tracking, and comprehensive reporting streamline evidence collection for assessments and incident investigations. Single-tenant private cloud or on-premises deployment supports data sovereignty. Consolidating multiple tools into one control plane reduces scope, simplifies documentation, and accelerates remediation of identified gaps.

To learn more about securing your endpoints for CMMC 2.0 compliance, schedule a custom demo today.